Background To study the branching enzyme, we performed several mutations on the branching enzyme gene. A mutation is a change in the DNA sequence of the gene which gives a change in the amino acid sequence it encodes. When the mutant protein is produced, information can be obtained from a study of changes compared to the wild type expression. For example, in the branching enzyme, the mutations effected the activity of the enzyme. Such changes in the catalytic efficiencies indicate that the amino acids might be important in catalysis. For enzymes, the structure determines function. Site directed mutagenesis can help us understand the structure function relationship of the enzyme.